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目的:通过Meta分析有关冠心病与睡眠呼吸暂停综合征(sleep apnea syndrome,SAS)关系的病例对照研究的文献,为冠心病与SAS相互关系的研究提供循证医学的证据。方法:收集和整理有关冠心病与SAS关系的病例对照研究的文献,观察对比冠心病和非冠心病患者群中SAS的发生率,用RevMan 5.2分析软件、Stata12SE分析软件对纳入的研究进行异质性检验和合并分析,结果以比数比(odds ratio,OR)表示,计算95%可信区间(95%CI),评估发表性偏倚和敏感性检验。结果:纳入的14组研究根据SAS定义不同分为两组分析,分析前9项研究显示OR=2.95,95%CI(2.25-3.87),P<0.05,差异有统计学意义;后5项研究R=3.42,95%CI(1.74-6.71),P<0.05,差异有统计学意义,表示SAS发生率与冠心病具有正的关联性,经检验不存在发表偏倚且敏感度分析示稳定度较高。结论:冠心病患者群中SAS的发生率高于非冠心病患者,SAS是冠心病的危险因素。
OBJECTIVE: To provide evidence-based evidence for the study of the relationship between coronary heart disease and SAS by Meta-analysis of case-control studies on the relationship between coronary heart disease and sleep apnea syndrome (SAS). Methods: A case-control study of the relationship between coronary heart disease and SAS was collected and collated. The incidence of SAS was compared between patients with coronary heart disease and non-coronary heart disease. RevMan 5.2 analysis software and Stata 12 SE analysis software were used to heterogeneously study the included studies Sex testing and pooled analysis, with odds ratios (OR) expressed as 95% confidence intervals (95% CI), assessed publication bias and sensitivity tests. Results: The 14 included studies were divided into two groups according to the different definitions of SAS. The first nine studies showed that OR = 2.95,95% CI (2.25-3.87), P <0.05, the difference was statistically significant. The last five studies R = 3.42,95% CI (1.74-6.71), P <0.05, the difference was statistically significant, indicating that the incidence of SAS and coronary heart disease have a positive correlation, published in the absence of publication bias and sensitivity analysis showed that the stability of more high. Conclusion: The prevalence of SAS in patients with coronary heart disease is higher than that in non-patients with coronary heart disease. SAS is a risk factor for coronary heart disease.