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目的 对两种双氯灭痛缓释片进行相对生物利用度的测定。方法 18名健康志愿者交叉服用两种双氯灭痛缓释片后,用高效液相色谱法测定不同时间的血药浓度,检测波长280nm,测定方法的线性范围为3~2000ng/ml(r=0.9998)。高中低3个浓度的回收率...
Objective To determine the relative bioavailability of two diclofenac tablets. Methods Eighteen healthy volunteers were treated with two sustained-release tablets of diclofenac. The plasma concentration of different doses of diclofenac was determined by HPLC at a wavelength of 280 nm. The linear range of the assay was 3 ~ 2000 ng / ml (r = 0. 9998). High school low concentration of 3 recovery ...