论文部分内容阅读
目的 评价鼻咽分泌物EB病毒检测在鼻咽癌诊断中的价值及了解鼻咽癌患者中的分布情况。方法 初诊未治的鼻咽癌患者 82例 ,其他癌瘤患者 64例 ,取鼻咽分泌物送检 ,PCR法检测EB病毒DNA。结果 鼻咽癌组 82例中 44例EB病毒阳性 ,检出率 5 5 .66% ,其他癌瘤组 64例中 6例EB病毒阳性 ,检出率 9.3 8% ,差异有显著性意义 (P <0 .0 0 5 )。本项检测的特异性 90 .63 % ,敏感性为 5 3 .66%。在鼻咽癌患者中 ,不同年龄、性别、病理类型的EB病毒检出率差异无统计学意义 ,原发灶T1、T2 、T3 、T4 病变的EB病毒检出率分别为 44 44% ,3 8 2 4% ,76 19%差异有显著性意义(P <0 .0 1)。结论 鼻咽分泌物EB病毒检测对鼻咽癌的诊断有一定价值 ,尤其是鉴别诊断的价值较高 ,原发灶高T分期的患者检出率高。
Objective To evaluate the value of nasopharyngeal secretions (EBV) detection in the diagnosis of nasopharyngeal carcinoma (NPC) and to understand the distribution of NPC in NPC patients. Methods 82 cases of untreated nasopharyngeal carcinoma and 64 cases of other carcinomas were enrolled in this study. Nasopharyngeal secretions were taken for detection, and Epstein-Barr virus DNA was detected by PCR. Results Among the 82 cases of nasopharyngeal carcinoma, 44 cases were positive for Epstein-Barr virus (EBV), the detection rate was 55.66%. Among 64 cases of other cancers, 6 cases were positive for Epstein-Barr virus (EBV), with a positive rate of 9.38% (P <0 0 0 5). The specificity of this test was 90.63% and the sensitivity was 53.66%. In NPC patients, there was no significant difference in the detection rate of Epstein-Barr virus among different age, gender and pathological types. The detection rates of EB virus in primary lesions T1, T2, T3 and T4 were 44 44%, 3 8 2 4%, 76 19% difference was significant (P <0. Conclusion The detection of nasopharyngeal secretions Epstein-Barr virus has some value in the diagnosis of nasopharyngeal carcinoma, especially in the differential diagnosis of high T-staging patients with high detection rate.