【摘 要】
:
Transdermal drug delivery system(TDDS)facilitates the con-trolled release of active ingredients penetrating through the skin,avoiding the liver first pass effect.Electrospinning is a simple process to fabricate ultrafine fibers with a higher specific sur-
【机 构】
:
Key Laboratory of Science & Technology of Eco-Textile,Ministry of Educa-tion,Shanghai Engineering Re
论文部分内容阅读
Transdermal drug delivery system(TDDS)facilitates the con-trolled release of active ingredients penetrating through the skin,avoiding the liver first pass effect.Electrospinning is a simple process to fabricate ultrafine fibers with a higher specific sur-face area,making them excellent candidates for drug delivery.In current work,a novel silk fibroin(SF)nanofiber loaded with cationic ethosomes(CEs)was prepared via green electrospinning.The data of Fourier transform infrared spectroscopy(FTIR)and laser scanning confocal microscopy(LSCM)confirmed the existence of CEs in the SF nanofibers.The morphology of the nanofibers was not significantly affected by the incorporation of CEs as shown by scanning electron microscopy(SEM)images.The CEs-loaded SF nanofibrous patch(CEs-SFnP)showed good cytocompatibility as proved by both cell counting Kit-8(CCK-8)assay and SEM.Using doxorubicin hydrochlo-ride(Dox)as a model drug,the transdermal performance of CEs-SFnP was evaluated through Franz diffusion cell against mouse skin.The results indicated that CEs-SFnP can effectively deliver drug into the skin,with a much higher permeation rate than the normal nanofibers without CEs.The as-spun CEs-SFnP in this study could find promising applications in TDDS.
其他文献
The alum-borneol nanoemulsion(ABN),which combines the mineral medicine alum and the botanical medicine borneol,has been applied for approximately 40 years in the clinical treatment of burns,scalds,radiation dermatitis and shingles,and has a good curative
The host-guest interactions between cyclopentanocucurbit-[6]uril(CyP6Q[6])as host and six alkyl imidazolium hydrochlo-ride as guests(g1,g2,g3,g4,g5,and g6)have been studied by various techniques,such as 1H NMR spectroscopy,isothermal titration calorimetry
Electrospinning with a simple and controllable process has ex-tremely received considerable concerns by virtue of the fab-rication and development of nanofibers.Moreover,nano-fibers are playing an increasing impact on energy conversion and storage devices
Antibacterial wound dressing can benefit the wound healing by preventing bacterial infection,especially for the electro-spun ones due to their porous structures and easily loading antibacterial drugs.However,it is challenging to apply the antibac-terial e
To reduce the cost of manufacture,it is urgent to develop effi-cient and stable platinum(Pt)-free counter electrode(CEs)electrocatalysts for dye-sensitized solar cells(DSSCs).In this study,a simple electrospinning and carbonization strategy has been devel
The research of photo-responsive materials,with changed ab-sorption and emission under light stimulus,has drawn more and more attention due to their wide applications.However,most of them suffered from the notorious aggregation-caused quenching(ACQ)effect
Low water vapor and air permeability is a persistent challengein wearable and on-skin electronics,as it reduces wearing comfort,and leads to skin irritation and inflammation in the long term.To tackle this issue,Zheng and coworkers designed a stretchable
Micro-size oil adsorbents are effective for the rapid reme-diation of special oil spills.Here,N-doped reduced gra-phene oxide(RGO)microspheres(ca.150 μm in diameter)with a local radially aligned and porous structure are fabricated by combining electrospra
In view of the current living micro-environment and requirements of green economy,intelligent light-responsive humidification materials have become a hot spot in intelligent polymer mate-rials.In this work,reversible photoresponsive films with a mechani-c
Janus membrane with opposite wettability on its two sides has witnessed an explosion of interest in the field of liquid sponta-neous and directional transport for their promising prospect.The advances in fabrication technology and natural bionics have bro