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THP(Tatmm-Horsfall protein)(又名Tatmm-Horsfall glycoprotein,THG或uromodulin)于1950年由Tatum和Horsfall用盐析法自尿液中提取并以他们的名字命名。THP是尿液中含量最多的蛋白质,由亨利氏袢升枝粗段以及远曲小管近端的上皮细胞分泌,对上皮细胞具有保护作用。成年人每天的分泌量为20～200mg,平均分泌量为40～50mgk。1985年Muchmore等自孕妇尿液中提取到一种蛋白质uromodulin,后经cDNA序列研究表明它的蛋白骨架与THP相同。近半个世纪来,THP的理化特性和生物特性已得到深入地
Tatum-Horsfall protein (also known as Tatmm-Horsfall glycoprotein, THG or uromodulin) was extracted from the urine by the salting-out method of Tatum and Horsfall in 1950 and was named after them. THP is the most abundant protein in the urine, which is secreted by the thick sections of Henrys ascending branch and epithelial cells near the distal convoluted tubule, which has a protective effect on epithelial cells. Adult daily secretion of 20 ~ 200mg, the average secretion of 40 ~ 50mgk. In 1985, Muchmore et al. Obtained a protein uromodulin from the urine of pregnant women, and the cDNA sequence showed that its protein skeleton is the same as that of THP. Nearly half a century, THP physicochemical properties and biological characteristics have been further