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目的分析胎儿宫内发育迟缓(IUGR)与胎儿脐血胰岛素、胰岛素样生长因子和脂联素的关系。方法选择2008年1月—2010年1月住院分娩的IUGR胎儿46例作为观察组,30例正常胎儿作为对照组,所有研究对象分娩后测定2组胎儿脐血的胰岛素、胰岛素样生长因子-1(IGF-1)和脂联素。并分析胎儿体质量与以上测定结果的关系。结果观察组胎儿脐血胰岛素、胰岛素样生长因子-1、脂联素分别为(3.2±1.2)μIU/ml、(54.2±15.4)μg/L和(29.4±13.4)μg/ml;对照组分别为(4.8±1.7)μIU/ml、(83.9±17.9)μg/L和(66.4±19.6)μg/ml。经t检验,观察组均明显低于对照组的正常胎儿,2组差异有统计学意义(t=3.0762,6.7106,5.2496,P<0.01)。相关分析显示观察组出生体质量与脐血中胰岛素、IGF-1和脂联素水平呈正相关(r=0.442,0.559,0.513,均P<0.05)。结论胎儿脐血胰岛素、胰岛素样生长因子-1和脂联素可以影响胎儿宫内发育,以上数据低可以引起胎儿宫内发育迟缓。
Objective To analyze the relationship between intrauterine growth retardation (IUGR) and fetal umbilical cord blood insulin, insulin-like growth factor and adiponectin. Methods 46 cases of IUGR fetuses hospitalized for delivery from January 2008 to January 2010 were selected as the observation group and 30 normal fetuses as control group. All the subjects were tested for insulin, insulin-like growth factor-1 (IGF-1) and adiponectin. And analyze the relationship between fetal body mass and the above results. Results The levels of insulin, insulin-like growth factor-1 and adiponectin in fetal umbilical cord blood of observation group were (3.2 ± 1.2) μIU / ml, (54.2 ± 15.4) μg / L and (29.4 ± 13.4) μg / (4.8 ± 1.7) μIU / ml, (83.9 ± 17.9) μg / L, and (66.4 ± 19.6) μg / ml. After t test, the observation group were significantly lower than the control group of normal fetuses, the two groups were statistically significant (t = 3.0762,6.7106,5.2496, P <0.01). Correlation analysis showed that the birth weight of the observation group was positively correlated with the levels of insulin, IGF-1 and adiponectin in cord blood (r = 0.442, 0.559, 0.513, all P <0.05). Conclusion Fetal umbilical cord blood insulin, insulin-like growth factor-1 and adiponectin can affect fetal intrauterine growth, the above data can cause low intrauterine growth retardation.