利多卡因是酰胺类麻醉剂中分子量最小的。在生理pH值条件下,其大部分发生电离,较其他大分子麻醉药更易于通过生物膜。Garcia-Martin等发现某些局麻药,包括利多卡因,可抑制ATP依赖的钙通道,阻断ca~(++)的流动。Shell及Wright报告利多卡因可以降低无机阳离子K~+,Na~+,Li~+,Rb~+等的通透性,从而抑制糖、氨基酸及三羧循环中间产物钠联(sodium-coupled)的运输。临床上,利多卡因除用于局部手术外,亦广泛应用于抗癌治疗中。在博莱霉素瘤体内浸润注射时利 Lidocaine is the smallest molecular weight amide anesthetic. Under physiological pH conditions, most of them undergo ionization and are easier to pass through biofilm than other macromolecular anesthetics. Garcia-Martin et al. found that certain local anesthetics, including lidocaine, inhibited ATP-dependent calcium channels and blocked the flow of ca~(++). Shell and Wright reported that lidocaine can reduce the permeability of inorganic cations K~+, Na~+, Li~+, Rb~+, etc., thereby inhibiting sodium-coupled sugars, amino acids, and intermediates in the tricarboxylic acid cycle. Transportation. Clinically, lidocaine is also widely used in anticancer therapy in addition to local surgery. Invasive injection of bleomycine in vivo