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应用自制循环密闭装置行甲基叔丁醚(MTBE)溶解胆囊结石研究。在14条杂种犬的胆囊内植入人胆固醇结石,将犬随机分为循环组及间断组各7条。用两种方法向胆囊内灌注MTBE2小时。溶石后计称结石所减重量及对胆囊、肝脏、十二指肠进行病理观察,比较两种方法溶石效果及毒副作用。结果表明,循环组溶石效果明显,而间断组十二指肠损害明显。
Study on Dissolution of Gallbladder Gallstones by Met-butyl-ether (MTBE) with Self-made Cyclic Closed Device. Human cholesterol gallstones were implanted into the gallbladder of 14 mongrel dogs. The dogs were randomly divided into 7 groups, 7 in the circulation group and 7 in the discontinuous group. MTBE was infused into the gallbladder in two ways for 2 hours. After the stone was dissolved, the weight of the stones was counted and pathological observations were made on the gallbladder, liver, and duodenum. The effects and toxic and side effects of the two methods were compared. The results showed that the effect of stone dissolution in the circulation group was obvious, while the duodenal damage was significant in the discontinuous group.