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随着社会老龄化进程加快,认知功能损害和痴呆发病率日益增高,成为严重影响老年人群健康和生命质量的重要病因。糖尿病不仅是阿尔茨海默病(AD)的独立危险因素,且其患AD的发病风险是非糖尿病的2倍。一线降糖药物二甲双胍,不仅能降低外周血糖,保护胰岛β细胞,增加IS;其在神经退行性疾病治疗领域的研究,近年来得到广泛关注。有研究称,二甲双胍能改善认知功能,而有的却认为其会增加糖尿病患者AD的发病风险。本文就二甲双胍对认知功能的影响及其可能机制作一综述,望其对糖尿病和AD的临床研究及治疗工作有所帮助。
With the acceleration of the social aging process, the incidence of cognitive impairment and dementia is increasing day by day, becoming an important cause of seriously affecting the health and quality of life of the elderly. Diabetes is not only an independent risk factor for Alzheimer’s disease (AD), but also has a 2-fold higher risk of developing AD than non-diabetes. The first-line hypoglycemic drug metformin can not only reduce peripheral blood glucose, protect pancreatic β-cells, and increase IS; its research in the field of neurodegenerative diseases has drawn wide attention in recent years. Some studies suggest that metformin can improve cognitive function, while others think it will increase the risk of AD in diabetic patients. In this paper, the impact of metformin on cognitive function and its possible mechanism are reviewed, looking forward to its clinical research and treatment of diabetes and AD helpful.