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目的 探讨血清a—L—岩藻糖苷酶在原发性肝癌诊断中的意义。方法 设定原发性肝癌组,慢性肝炎、肝硬化组,脂肪肝,其他恶性肿瘤,正常对照组,测定各组的a—L—岩藻糖苷酶水平。在原发性肝癌组中,做血清AFP,AFU的测定。AFU采用比色法,AFP采用ELISA酶标比色法。结果 253例原发性肝癌患者中,AFP>20μg/L的阳性率为70.75％,AFU阳性 率为75.49％。AFP与AFU的联合应用阳性者为232例,阳性率为91.70％,两者同时阳性者为137例,阳性率为54.15％。AFP在200～400μg/L的154例中,AFU阳性者为116例,占75.32％,AFP20～200μg/L阳性者的25例中,AFU阳性者为21例,占84％。AFP<20μg/L的74例,AFU阳性者为53例,占71.62％。结论 AFU检测可弥补AFP低水平的不足,是一个诊断原发性肝癌的有效血清酶学指标。AFU和AFP对PHC的诊断敏感性、特异性各有所长,联合应用可优势互补,阳性率可显著提高,对临床诊断及判断病情,疾病的转归有较大的参考价值。
Objective To investigate the significance of serum a-L-fucosidase in the diagnosis of primary liver cancer. Methods The primary liver cancer group, chronic hepatitis, cirrhosis group, fatty liver, other malignant tumors, and normal control group were set up. The a-L-fucosidase level in each group was determined. In the primary liver cancer group, serum AFP and AFU were measured. AFU uses colorimetry, and AFP uses ELISA enzyme colorimetry. Results Of 253 patients with primary liver cancer, the positive rate of AFP>20 μg/L was 70.75%, and the positive rate of AFU was 75.49%. The positive rate of AFP and AFU was 232 cases, and the positive rate was 91.70%. The positive rate was 137 cases, and the positive rate was 54.15%. Among the 154 cases with AFP at 200-400 μg/L, 116 cases were AFU-positive, accounting for 75.32%. Of the 25 cases with positive AFP 20-200 μg/L, 21 were AFU-positive, accounting for 84%. AFP was less than 20 μg/L in 74 patients, and 53 patients were AFU-positive, accounting for 71.62%. Conclusion The detection of AFU can make up for the low level of AFP. It is an effective serum enzyme for the diagnosis of primary liver cancer. The sensitivity and specificity of AFU and AFP in the diagnosis of PHC have their own advantages. The combined use of the advantages and specificities can be complementary, the positive rate can be significantly improved, and has great reference value for the clinical diagnosis and judgment of the disease, the outcome of the disease.