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目的 :观察 SARS患者临床表现变化规律并寻找早期诊断线索。方法 :收集 2所收治 SARS病例医院的 2 2 5名患者的临床病历资料进行回顾性分析 ,包括发病 -住院时间、症状、白细胞和中性粒细胞、X线等资料。结果 :2 2 5名患者中男性 1 2 1名 ,女性 1 0 4名 ,患者年龄基本一致 ,平均入院时间为 7.4 5 d。住院前症状与首发症状中发热出现比例分别为 99.1 1 %和97.33% ,住院前咳嗽和胸闷症状出现的比例显著高于首发症状 (P<0 .0 5 ) ;白细胞总数和中性粒细胞比例在病程 0～ 8d明显低于病程 9～ 1 4 d(P<0 .0 5 ) ;胸部 X线在发病 3d后有 96 .0 %～ 1 0 0 .0 %的病例出现异常。结论 :利用患者的临床症状、白细胞、中性粒细胞和 X线的动态变化规律可为 SARS早期诊断提供线索
Objective: To observe the change of clinical manifestations in SARS patients and find out the early diagnosis clues. Methods: The clinical data of 2 250 patients admitted to two SARS hospital were collected and analyzed retrospectively, including incidence-hospital stay, symptoms, leukocyte and neutrophil, X-ray and so on. Results: Of the 225 patients, 121 were males and 104 were females. The patients were all of the same age and the average admission time was 7.45 days. Pre-hospital symptoms and first symptom onset fever were 99.1 1% and 97.33% respectively, and the incidence of cough and chest tightness before hospitalization was significantly higher than that of the first symptom (P <0.05); the total number of leukocytes and neutrophil percentage The duration of disease ranged from 0 to 8 days was significantly lower than the duration of disease from 9 to 14 days (P <0. 05). The chest X-ray showed abnormalities in 96.0% -100.0% of the cases after 3 days of onset. Conclusion: The dynamic changes of white blood cells, neutrophils and X-rays can provide clues to the early diagnosis of SARS by using the clinical symptoms of patients