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目的：探讨慢性肾功能不全（ Ｃ Ｒ Ｆ）患者血浆心钠素Ⅱ（ Ａ Ｎ Ｐ）、 Ｃ Ｒ Ｆ患者治疗前后血管紧张素（ ＡⅡ）的变化及意义。方法：采用放免法检测血浆 Ａ Ｎ Ｐ及 ＡⅡ水平，同时设正常对照。结果：① Ｃ Ｒ Ｆ患者 Ａ Ｎ Ｐ 与 ＡⅡ水平较正常明显升高。② Ｃ Ｒ Ｆ 患者血尿素氮（ Ｂ Ｕ Ｎ）与 Ａ Ｎ Ｐ 水平呈正相关，与 ＡⅡ无相关性。肌酐清除率（ Ｃ Ｃｒ）、２４ ｈ 尿钠和尿蛋白定量与 Ａ Ｎ Ｐ、 ＡⅡ无明显相关， Ａ Ｎ Ｐ与 ＡⅡ亦不相关。③高血压组用洛汀新治疗后，血压降至正常高限水平， ＡⅡ明显下降， Ａ Ｎ Ｐ 无明显改变。结论： Ｃ Ｒ Ｆ失代偿期患者血中 Ａ Ｎ Ｐ及 ＡⅡ水平升高。
Objective: To investigate the changes and clinical significance of angiotensin Ⅱ (AⅡ) in patients with chronic renal insufficiency (C R F) before and after treatment of plasma atrial natriuretic peptide (A N P) and C R F patients. Methods: Radioimmunoassay was used to detect plasma A N P and AⅡ levels and normal control. Results: ① The levels of A N P and AⅡ in patients with C R F were significantly higher than those in patients with normal controls. ② There was a positive correlation between blood urea nitrogen (B U N) and A N P level in patients with C R F, but no correlation with A Ⅱ. Creatinine clearance rate (C Cr), 24 h urinary sodium and urinary protein quantification and A N P, A Ⅱ no significant correlation, A N P and A Ⅱ are not related. ③ hypertension with Lotensin treatment, the blood pressure dropped to the normal high level, A Ⅱ decreased significantly, A N P no significant change. CONCLUSIONS: Blood levels of A N P and AII are elevated in patients with decompensated C R F.