混合性冷球蛋白血症(ＭＣ)是一种较少见的系统性疾病。1966年,Ｍｅｌｔｚｅｒ[1]首先报道了一种综合征,其主要的临床表现为紫癜、乏力、关节痛和肾小球肾炎,偶有胃肠道、心肺和神经系统等血管炎的系统症状。这些患者常伴有肝脏病变,部分可以多年无症状,但其中许多患者肝脏病变 Mixed cryoglobulinemia (MC) is a less common systemic disease. In 1966, Meltzer [1] first reported a syndrome whose main clinical manifestations were systemic symptoms of vasculitis such as purpura, fatigue, joint pain and glomerulonephritis, occasional gastrointestinal tract, cardiopulmonary and nervous system. These patients are often accompanied by liver disease, some can be asymptomatic for many years, but many of these patients with liver disease