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有资料表明,安宫黄体酮(醋酸甲孕酮,Med-roxyprogesterone Acetate,MPA)大剂量非肠道投入,可削弱胰岛素依赖型糖尿病患者的血糖控制,机理尚不清楚。本研究旨在了解 MPA 对糖尿病鼠肝糖代谢的影响。21只重250～300g 的雄 Wistar 大鼠随机分3组。甲、乙两组腹腔内注射链脲菌素(Streptozo-tocin,亚硝基脲化合物,能毁坏胰岛的β细胞,诱发糖尿病)60mg/kg/日,3天后出现糖尿。继而,甲组腹腔内注射 MPA100mg/kg/日,连续7天。乙组则注射0. 9M Nacl 溶液。丙组未作任何处理,
Some data indicate that high doses of parenteral medroxyprogesterone acetate (Medroxyprogesterone Acetate, MPA) can reduce the glycemic control in patients with insulin-dependent diabetes mellitus, the mechanism of which is unclear. This study aimed to understand the effects of MPA on glycogen metabolism in diabetic mice. Twenty-one male Wistar rats weighing 250-300 g were randomly divided into three groups. A and B were intraperitoneally injected with streptozotocin (nitrosourea compound, β-cell that can destroy the islets, induced diabetes mellitus) 60mg / kg / day, 3 days after the onset of diabetes. Then, Group A intraperitoneal injection of MPA100mg / kg / day for 7 days. Group B is injected 0. 9M Nacl solution. Group C did not make any treatment,