骨肉瘤是青少年常见的原发恶性骨肿瘤。过去进行单纯截肢术治疗,术后五年生存率在5～15％左右,根治术后1～2年内80～90％死于肺转移。自骨肉瘤术后应用大剂量氨甲喋呤及甲酰四氢叶酸钙解救疗法(HD-MTX-CFR)以来,疗效一跃而提高到36～77％,取得了重大突破,引起 Osteosarcoma is a common primary malignant bone tumor in adolescents. In the past, simple amputation was performed. The 5-year survival rate was about 5 to 15% after surgery. 80 to 90% of the patients died of lung metastasis within 1 to 2 years after radical resection. Since the application of high-dose methotrexate and calcium folinate-recovery therapy (HD-MTX-CFR) after osteosarcoma surgery, the curative effect has risen to 36 to 77% and a major breakthrough has been made.