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目的探讨对子宫肌瘤患者行子宫动脉栓塞治疗(UAE)对生育功能的影响。方法对广州市第一人民医院1999-06-01-2005-12-30因子宫肌瘤行UAE的病例进行追踪观察,了解治疗后妊娠情况及结局。结果694例中有34例35次自然受孕。其中613例没有生育要求的患者中,有18例19次意外受孕,其中人工流产10例,药物流产8例9次,自然流产1例。81例有生育要求者受孕者16例次,均为宫内妊娠。有4名行人工流产的患者取其新鲜绒毛组织作染色体检查均正常。其中足月分娩8例,5例剖宫产,3例顺产。目前仍在正常妊娠中5例,分别为孕70d、18+周、28+周,30+周和33+周,2例在孕16~18周抽羊水作染色体检查未发现异常,2例孕30周后行彩色超声检查未见胎儿畸形。1例自然流产,2例分别在妊娠3个月和7个月时复诊1次后失访。8名新生儿出生后常规体格检查及筛查实验(地中海贫血、甲状腺功能低下和丙酮酸尿症)均未发现异常,现年龄为3-33个月。结论子宫肌瘤UAE治疗后可以正常受孕和分娩,自然受孕的时间一般在治疗后1~2年内。
Objective To investigate the effect of uterine artery embolization (UAE) on fertility in patients with uterine fibroids. Methods The first People’s Hospital of Guangzhou City 1999-06-01-2005-12-30 uterine fibroids UAE cases were followed up to understand the situation and outcome after treatment of pregnancy. Results Of the 694 cases, 34 cases naturally congealed 35 times. Among 613 patients who did not have childbearing requirements, 18 cases of unintended pregnancy occurred in 19 cases, including 10 cases of induced abortion, 8 cases of drug abortion and 9 cases of spontaneous abortion. 81 cases of fertility requirements were pregnant 16 cases times, are intrauterine pregnancy. There are 4 patients abortion abortion of fresh villi tissue for chromosomal examination were normal. 8 cases of full-term delivery, 5 cases of cesarean section, 3 cases of spontaneous. At present, there are still 5 cases of normal pregnancy, respectively, pregnant 70d, 18 + weeks, 28 + weeks, 30 + weeks and 33+ weeks, 2 cases of pregnancy 16-18 weeks of amniotic fluid for chromosomal abnormalities found no abnormalities, 2 cases of pregnancy Thirty weeks after color ultrasound examination showed no fetal malformations. One case of spontaneous abortion, two cases were lost to follow-up visit at 3 months and 7 months respectively. Eight newborns after birth, physical examination and screening tests (thalassemia, hypothyroidism and pyruvateuria) were found no abnormalities, now aged 3-33 months. Conclusion UAE treatment of uterine fibroids can be normal pregnancy and childbirth, the time of natural conception generally within 1 to 2 years after treatment.