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[目的]研究淫羊藿提取物对去卵巢大鼠骨密度、血清雌二醇的影响。[方法]取84只雌性大鼠随机分成假手术组（A组）、去卵巢骨质疏松模型组（B组）、己烯雌酚组（C组）、骨疏康组（D组）、淫羊藿提取物高剂量组（E组）、中剂量组（F组）、低剂量组（G组）7组，每组12只。造模成功后，饲养90 d ，开始灌胃90 d后，检测离体骨骨密度、血清雌二醇。[结果]B组大鼠离体骨骨密度、血清雌二醇水平均明显低于其他6组（P ＜0．05）；A组、B组、C组、D组、E组、F组、G组之间比较无明显统计学差异（P ＞0．05）。[结论]淫羊藿提取物可提高去卵巢大鼠离体骨骨密度和血清雌二醇水平，对实验大鼠去卵巢所致骨质疏松症有明显的治疗作用。“,”[Objective] To study the effect of epimedium extract on bone mineral density and serum estra-diol in ovariectomized rats .[Methods]A total of 84 female rats were chosen and randomly divided into sham operations group (group A ) , ovariectomized osteoporosis model group (group B ) , diethylstilbestrol group (group C) ,gushukang group(group D) ,high dose of epimedium extract group(group E) ,middle dose of epi-medium extract group(group F) and low dose of epimedium extract group (group G) with 12 rats in each group .After successful model establishment ,bone mineral density and serum estradiol of bone in vitro at 90d after feed and lavage .[Results]Bone mineral density and serum estradiol in rat bone of group B were obviously lower than those in other 6 groups( P 0 .05) .[Conclusion] Epimedium extract can increase bone mineral density and serum estradiol in bone of ovariectomized rats in vitro ,and has obvious efficacy for the treatment of osteoporosis caused by ovariectomy in rats .