多年来,人们推测炎症性肠病的发病机制与自身免疫有关。但作为自身免疫性疾病是否有足够的证据? 严格地讲,作为一种自身免疫性疾病要求有对本病特异的自身反应性淋巴细胞和/或自身抗体,及能同基因转移本病。按较低标准,提示与自身免疫有关的标准为:1.血液中有疾病特异的自身抗体,如重症肌无力者的抗乙酰胆碱抗体,原发性胆汁性肝硬化者的抗线粒体抗体;2.与其他自身免疫性疾病有联系;3.伴有一种或多种HLA单倍型;4.活动性病变部位有淋巴细胞浸润和上皮细胞表达HLA Ⅱ型抗原;5.皮质激素 Over the years, it is speculated that the pathogenesis of inflammatory bowel disease and autoimmune related. But is there enough evidence as an autoimmune disease? Strictly speaking, autoimmune lymphocytic and / or autoantibodies specific to this disease are required as an autoimmune disease and the disease can be syngeneic transferred. According to the lower standard, the tips related to autoimmunity are as follows: 1. There are disease-specific autoantibodies in blood, such as anti-acetylcholine antibody in myasthenia gravis and anti-mitochondrial antibody in primary biliary cirrhosis; Associated with other autoimmune diseases; 3. associated with one or more HLA haplotypes; 4. active lesions with lymphocytic infiltration and epithelial cells expressing HLA type II antigen; 5. corticosteroids