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世界卫生组织基本药物目录(WHO EML)评价、遴选经过38年发展,申请流程更加科学、规范。但针对WHO EML申请的外部专家评审常需在短时间内快速完成,急需建立一套科学、规范、透明的快速评审方法和流程。WHO EML外审专家循证快速评估方法和流程要点包括:1确定评估需求:基于申请材料,明确评审目的。2构建问题:基于评审目的,转化为PICOS要素。3文献检索与筛选:优先检索、纳入SR或Meta分析、HTA、临床指南等。4资料提取:基于评审目的,提取主要信息。5文献合成与评价:基于评审要求,定性描述,比较评价结果。6形成推荐:明确给出是否同意申请的意见、证据质量和推荐强度。探索建立的WHO EML外审专家循证快速评估的方法和流程已用于指导笔者承担的第19版WHO EML的评审工作,证实其切实可行,且能满足快速评估的时间和质量要求,但仍需在实践检验中不断完善。
WHO EML evaluation, selection After 38 years of development, the application process is more scientific and standardized. However, the evaluation of external experts for WHO EML applications often needs to be completed quickly and in a short period of time. There is an urgent need to establish a scientific, standardized and transparent quick assessment method and process. WHO EML external audit expert evidence-based rapid assessment methods and process highlights include: 1 to determine the assessment needs: based on the application materials, a clear review of the purpose. 2 Building Issues: Converted to PICOS Elements for review purposes. 3 literature search and screening: priority search, including SR or Meta analysis, HTA, clinical guidelines. 4 data extraction: based on the purpose of the review, to extract the main information. 5 literature synthesis and evaluation: Based on the review requirements, qualitative description, evaluation results. 6 Form a Recommendation: Specify clearly whether to approve the application, the quality of the evidence, and the strength of the recommendation. The methods and procedures for establishing the rapid evidence-based evaluation of WHO EML external auditors have been used to guide the author’s review of the WHO EML version 19 to confirm that it is feasible and meet the time and quality requirements for rapid assessment. However, Need to be constantly improved in practice test.