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目的总结micro RNA对肿瘤微环境的调控机制。方法通过检索Pub Med获取近年来关于micro RNA对肿瘤细胞微环境调控机制的相关文献资料并进行综述。结果 micro RNA可以参与低氧诱导因子、肿瘤相关成纤维细胞、细胞外基质等肿瘤微环境因素在转录后水平表达的调控,微环境的变化会导致肿瘤细胞生物学行为的改变。结论 micro RNA参与调节肿瘤微环境的诸多因素,而微环境的改变对于肿瘤的发生、发展有着至关重要的作用,明确micro RNA对微环境调控的机制不仅有助于探索肿瘤细胞生物学行为,同样为肿瘤疾病的诊断和预后提供新的思路。
Objective To summarize the regulatory mechanism of micro RNA on tumor microenvironment. Methods PubMed was searched to retrieve and review the recent literature on microRNA regulation of microenvironment in tumor cells. Results MicroRNA could be involved in the regulation of the expression of tumor microenvironment factors such as hypoxia-inducible factor, tumor-associated fibroblasts and extracellular matrix at post-transcriptional level. The changes of microenvironment lead to the change of biological behavior of tumor cells. Conclusion MicroRNA is involved in many factors that regulate tumor microenvironment, and microenvironment changes are crucial for tumorigenesis and development. To clarify the mechanism by which microRNA regulates microenvironment not only helps to explore the biological behavior of tumor cells, The same for the diagnosis and prognosis of cancer disease provide new ideas.