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目的探讨血清抗α-胞衬蛋白IgA抗体在原发性干燥综合征(pSS)诊断中的意义。方法应用酶联免疫吸附试验检测42例pSS患者和77例健康正常人血清抗α-胞衬蛋白IgA抗体水平,分析其与pSS患者临床资料的相关性。结果血清抗α-胞衬蛋白IgA抗体诊断pSS的敏感性为33.3%,特异性为92.2%;pSS患者血清抗α-胞衬蛋白IgA抗体阳性与口干症、眼干症、腮腺肿大显著相关(P<0.05),与肺间质纤维化、肾小管酸中毒、肝损害无显著相关(P>0.05)。结论血清抗α-胞衬蛋白IgA抗体对诊断pSS的敏感性较差、特异性较好,对判断pSS腺体功能可能具有一定的临床意义。
Objective To investigate the significance of serum anti-α-globin IgA antibody in the diagnosis of primary Sjogren’s syndrome (pSS). Methods Serum anti-α-globin IgA antibody levels were measured in 42 pSS patients and 77 healthy controls by enzyme-linked immunosorbent assay (ELISA), and their correlations with clinical data of pSS patients were analyzed. Results The serum anti-α-globin IgA antibody was 33.3% and the specificity was 92.2%. Serum anti-α-globin IgA antibody in patients with pSS was significantly associated with dry mouth, dry eye and parotid gland (P <0.05). There was no significant correlation between interstitial fibrosis, renal tubular acidosis and liver damage (P> 0.05). Conclusions Serum anti-α-globin IgA antibody has poor sensitivity and specificity for the diagnosis of pSS, and may be of clinical significance for judging pSS gland function.