研究者凭借对端粒的功能和维持机制的阐述在2009年获得了诺贝医学奖[1],这些研究者发现了端粒是一段位于真核生物线性染色体末端的DNA-蛋白复合体,通过防止染色体的末端融合来维持染色体的稳定,端粒酶通过对端粒的损伤后修复来维持端粒的稳定。在这篇综述中,阐述的是这些发现在肿瘤中的应用。在人体细胞中,限制细胞生长的两个机制:衰老和生长停滞是防止癌症的有效机制,当平均端粒长度达到大约5 The researchers won the Nobel Prize in Medicine in 2009 for their elucidation of the function and maintenance mechanisms of telomeres [1]. These researchers found that telomeres are DNA-protein complexes located at the ends of linear chromosomes of eukaryotes by Prevent chromosomal end fusion to maintain chromosomal stability, telomerase through telomere repair after injury to maintain telomere stability. In this review, we describe the use of these findings in oncology. In human cells, two mechanisms that limit cell growth: aging and growth arrest are effective mechanisms to prevent cancer when the average telomere length reaches about 5