肝静脉闭塞病是一种以肝小静脉纤维性闭塞为主要病理改变的疾病。骨髓移植后肝静脉闭塞病是近年来才被逐渐认识的一种合并症,因其发生率较高且多为致死性的,是影响骨髓移植疗效的主要因素之一。鉴于国内尚无系统报道,本文就骨髓移植后肝静脉闭塞病的发病因素和机理、临床表现、病理学改变、诊断和防治等作一概要介绍。 Hepatic veno-occlusive disease is a disease characterized by hepatic venular fibrillation as the major pathological change. Hepatic vein occlusive disease after bone marrow transplantation is a complication that has been gradually recognized in recent years. Because of its high incidence and mostly lethality, it is one of the main factors that affect the efficacy of bone marrow transplantation. In view of the absence of systematic reports in our country, this article gives an overview of the pathogenesis and mechanism of hepatic veno-occlusive disease after bone marrow transplantation, clinical manifestations, pathological changes, diagnosis and prevention.