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目的:探讨原发性高血压患者抗AT1受体自身抗体与白细胞介素(IL)-4、干扰素(IFN)-γ的关系,以初步了解抗AT1抗体的产生机制。方法:用ELISA方法检测76例原发性高血压患者血清抗AT1抗体、IL-4和IFN-γ的水平,比较抗AT1抗体阳性和阴性组之间IL-4和IFN-γ水平的差异。结果:76例患者中,抗AT1受体抗体阳性和阴性者分别为42和34例,抗体阳性组血清IL-4水平显著高于抗体阴性组[(13.21±0.92)ng/L∶(11.64±0.77)ng/L,P<0.01];而IFN-γ在抗体阳性组与抗体阴性组之间差异无统计学意义[(14.68±2.53)ng/L∶(15.45±1.48)ng/L,P>0.05]。结论:抗AT1受体抗体阳性高血压患者血清IL-4水平高于抗体阴性组患者,Th2细胞功能亢进可能是原发性高血压患者抗AT1受体抗体产生的机制之一。
Objective: To investigate the relationship between anti-AT1 receptor autoantibodies against interleukin-4 (IL-4) and interferon-γ (IFN-γ) in patients with essential hypertension to understand the mechanism of anti-AT1 antibody. Methods: The levels of anti-AT1 antibody, IL-4 and IFN-γ in serum of 76 patients with essential hypertension were detected by ELISA. The differences of IL-4 and IFN-γ levels between anti-AT1 antibody positive and negative groups were compared. Results: Among the 76 patients, the antibody positive and negative for AT1 receptor were 42 and 34 respectively. The level of IL-4 in antibody positive group was significantly higher than that in antibody negative group [(13.21 ± 0.92) ng / L vs (11.64 ± 0.77) ng / L, P <0.01]. There was no significant difference in IFN-γ between the antibody-positive group and the antibody-negative group [(14.68 ± 2.53) ng / L vs (15.45 ± 1.48) ng / > 0.05]. CONCLUSION: Serum IL-4 level is higher in anti-AT1 receptor antibody-positive hypertensive patients than in antibody negative patients. Th2 cell hyperfunction may be one of the mechanisms of anti-AT1 receptor antibody in patients with essential hypertension.