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甲状腺机能减退症(hypothyroidism,简称甲减)是由多种原因引起的甲状腺激素合成、分泌或组织利用不足所致的全身代谢减低综合症。甲减是大多数甲状腺疾病的最终转归。甲减起病于胎儿或新生儿者称呆小病;起病于儿童者称幼年型甲减;起病于成年者为成年型甲减。临床甲减的患病率为1%左右,随着年龄的增加,甲减患者逐渐增多,以女性多见。甲减的病因复杂,以原发者多见,其次为垂体性者,其他均属少见。近年来国内外为更好地研究甲减病因、发病机制、病理过程,纷纷尝试建立各种甲减动物模型,便于实验研究。现结合有关文献就近年甲减动物模型的研究进展作一回顾。
Hypothyroidism (Hypothyroidism, hypothyroidism) is caused by a variety of causes of thyroid hormone synthesis, secretion or tissue utilization due to systemic metabolic syndrome. Hypothyroidism is the ultimate outcome of most thyroid diseases. A hypothyroidism in the fetus or newborn were said to stay ailment; onset in children that juvenile hypothyroidism; onset in adults for adult hypothyroidism. The prevalence of clinical hypothyroidism is about 1%, with age, hypothyroidism patients gradually increased, more common in women. The etiology of hypothyroidism complicated by the more common primary, followed by pituitary, others are rare. In recent years, at home and abroad in order to better study the cause of hypothyroidism, pathogenesis, pathological process, have tried to establish various models of hypothyroidism, easy to experimental study. Now with the relevant literature review of hypothyroid animal models in recent years made a review.