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目的了解广西乙型肝炎病毒(HBV)性传播状况。方法对我们2004年建立的隆安研究队列HBsAg无症状携带者的配偶采静脉血收集血清,用酶联免疫吸附试验检测HBV血清学标志物。结果 217名研究对象中,96.8%(210/217)有过去或目前感染乙肝病毒的标记,其中32例HBsAg阳性,阳性率为14.7%(32/217),男、女阳性率分别为15.4%(14/91)和14.3%(18/126),差异无统计学意义(χ2=0.051,P>0.05);107例HBsAb阳性,阳性率为49.3%(107/217);一名男性HBsAg和HBsAb同时阳性;有79例HBsAg,anti-HBs and HBeAg阴性,这79例要么抗-HBc和抗-HBe同时阳性,要么单项阳性,但都是HBVDNA阴性;有7人(包括男性3人、女性4人)没有任何乙肝感染标记,包括HBVDNA阴性。另外,122名HBVDNA阳性的HBsAg携带者其配偶(研究对象)有14人HBsAg阳性;95名HBVDNA阴性的HBsAg携带者其配偶有18人HBsAg阳性,两者阳性率无统计学差异(χ2=2.372,P>0.05)。HBeAg阴、阳性的HBsAg携带者其配偶的HBsAg阳性率分别为15.61%(27/173)和11.76%(4/34),两者也无统计学差异(χ2=0.093,P>0.05)。结论配偶因密切接触HBsAg携带者而受HBV感染的机会比一般人群大,但性别、病毒量和HBeAg不影响其配偶感染HBV的机会。
Objective To understand the status of sexual transmission of hepatitis B virus in Guangxi. Methods Serum was collected from the spouses of the spouses of HBsAg asymptomatic carriers of Longan study cohort established in 2004 and HBV serological markers were detected by enzyme-linked immunosorbent assay. Results Of the 217 subjects, 96.8% (210/217) had past or present signs of hepatitis B virus infection, of which 32 cases were positive for HBsAg and the positive rate was 14.7% (32/217). The positive rates of male and female were 15.4% (14/91) and 14.3% (18/126) respectively, with no significant difference (χ2 = 0.051, P> 0.05). The positive rate of HBsAb in 107 cases was 49.3% (107/217) HBsAb positive at the same time; there were 79 cases of HBsAg, anti-HBs and HBeAg negative, the 79 cases of either anti-HBc and anti-HBe positive, either single positive, but are negative for HBVDNA; 7 (including 3 males, 4) did not have any signs of hepatitis B infection, including HBVDNA negative. In addition, 122 HBsAg positive HBsAg carriers had 14 spouses (study subjects) positive for HBsAg; 95 HBsAg negative HBsAg carriers had 18 spouses HBsAg positive, with no significant difference (χ2 = 2.372 , P> 0.05). HBsAg positive and HBsAg positive HBsAg positive rate of their spouses were 15.61% (27/173) and 11.76% (4/34) respectively, with no significant difference (χ2 = 0.093, P> 0.05). Conclusion The chances of spouse receiving HBV infection due to close contact with HBsAg carriers are greater than that of the general population. However, gender, viral load and HBeAg do not affect their spouses’ chances of HBV infection.