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探讨慢性疲劳综合征 (CFS)肝郁脾虚证患者血中NK细胞活性、免疫球蛋白的改变及消疲怡神口服液治疗慢性疲劳综合征的作用机理。观察了 4 8例CFS患者服用“消疲怡神口服液”前后及30例正常对照者血中NK细胞活性及免疫球蛋白含量。结果 :CFS病人外周血的NK细胞活性及免疫球蛋白水平较正常对照组显著下降 ,服用“消疲怡神口服液”后 ,降低的NK细胞活性及免疫球蛋白含量具有显著的上升 ,其中部分值接近正常对照组。结论 :CFS患者存在免疫功能下降 ,服药后患者临床症状明显改善 ,结合免疫功能改善 ,说明该药治疗CFS的作用机制与提高免疫功能有关
To investigate the changes of NK cell activity and immunoglobulin in blood of chronic fatigue syndrome (CFS) patients with liver depression and spleen deficiency syndrome and the mechanism of Xiaoshiyishen oral liquid in treating chronic fatigue syndrome. The NK cell activity and immunoglobulin content in blood of 48 CFS patients before and after taking Xiaofei Yishen Oral Liquid and 30 normal controls were observed. RESULTS: The peripheral blood NK cell activity and immunoglobulin levels of CFS patients were significantly lower than those of the normal control group. After taking “Xiaixiuyi Oral Solution”, the decreased NK cell activity and immunoglobulin content had a significant increase. The value is close to the normal control group. Conclusion: The immune function of CFS patients was decreased. The clinical symptoms of the patients after CFS administration were significantly improved, combined with the improvement of immune function, indicating that the mechanism of action of this drug in the treatment of CFS is related to the improvement of immune function.