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在碳酸钾催化下,碳酸二甲酯与甘油发生酯交换合成碳酸甘油酯,再以碳酸甘油酯、2-溴异丁酰溴为原料,发生醇解反应合成2-氧代-1,3-二氧戊环-4-基-(甲基-2-溴-2-甲基丙酸甲酯)(ODMBMP)。借助原子转移自由基聚合(ATRP)技术,氯化亚铜(CuCl)/2,2′-联二吡啶(bpy)为催化体系,以ODMBMP为引发剂,引发甲基丙烯酸甲酯(MMA)和甲基丙烯酸环氧丙酯(GMA)无规共聚,合成环状碳酸甘油酯单封端聚甲基丙烯酸甲酯-甲基丙烯酸环氧丙酯无规聚合物(PMMA-co-GMA)。最后,以PMMA-co-GMA和三甲胺盐酸盐为原料,通过开环季铵化反应生成具有水溶性的季铵化聚甲基丙烯酸甲酯-甲基丙烯酸环氧丙酯无规聚合物(QPMMA-co-GMA)。采用红外光谱(IR)、凝胶色谱(GPC)、核磁共振氢谱(1 H-NMR)等技术对合成物质的结构和性能进行表征。利用最小杀菌浓度(MBC)法,测定合成的QPMMA-coGMA对金黄色葡萄球菌的杀菌活性,实验结果表明在浓度80mg/L时,杀菌率为99.9%。
Under the catalysis of potassium carbonate, dimethyl carbonate and glycerol are transesterified to synthesize carbonic acid glycerides, then glycerol carbonate and 2-bromoisobutyryl bromide are used as raw materials to undergo alcoholysis reaction to synthesize 2-oxo-1, 3- Dioxolan-4-yl- (methyl-2-bromo-2-methylpropionate) (ODMBMP). With the aid of atom transfer radical polymerization (ATRP), cuprous chloride (CuCl) / 2,2’-bipyridyl (bpy) as catalyst system and methyl methacrylate (MMA) as initiator and ODMBMP as initiator Synthesis of cyclic monoglyceride mono-terminated polymethyl methacrylate-glycidyl methacrylate random copolymer (PMMA-co-GMA) was carried out by random copolymerization of glycidyl methacrylate (GMA). Finally, PMMA-co-GMA and trimethylamine hydrochloride were used as starting materials to produce water-soluble quaternized poly (methyl methacrylate-glycidyl methacrylate) random polymers by ring-opening quaternization (QPMMA-co-GMA). The structure and properties of the synthesized materials were characterized by IR, GPC and 1 H-NMR. The bactericidal activity of the synthesized QPMMA-coGMA against Staphylococcus aureus was determined by the minimum bactericidal concentration (MBC) method. The experimental results showed that the bactericidal rate was 99.9% at the concentration of 80mg / L.