论文部分内容阅读
目的探讨宫颈小细胞神经内分泌癌的临床病理特征、诊断、治疗及预后。方法回顾性分析2006年4月至2011年10月在河南省肿瘤医院收治的6例神经内分泌癌患者的临床病理资料、治疗方式及预后。结果6例患者平均年龄42.5岁,IB期2例,IIA期4例,临床症状主要为阴道出血,均无全身内分泌症状。全部患者均经病理检查,其中5例经免疫组化确诊,2例有淋巴结转移。6例患者中1例确诊后放弃治疗,4个月后死亡,余5例均接受综合治疗,2例患者已死亡,生存期分别为23个月,21个月,3例患者仍在治疗随访中。结论 SC-NCC恶性度高,易早期转移,预后差,死亡率高。其诊断主要依靠病理组织形态学和免疫组化。目前尚没有规范有效的治疗方案,现大多采用手术、化疗和放疗联合综合治疗。
Objective To investigate the clinicopathologic features, diagnosis, treatment and prognosis of cervical small cell neuroendocrine carcinoma. Methods The clinical and pathological data, treatment methods and prognosis of 6 patients with neuroendocrine carcinoma admitted to Cancer Hospital of Henan Province from April 2006 to October 2011 were retrospectively analyzed. Results The average age of 6 patients was 42.5 years, 2 cases were in stage IB, 4 cases were in stage IIA. The main clinical symptoms were vaginal bleeding without any systemic endocrine symptoms. All patients were pathologically examined, of which 5 cases were confirmed by immunohistochemistry and 2 cases with lymph node metastasis. One of six patients gave up their treatment after diagnosis, and died after four months. The other five patients were treated comprehensively. Two patients died and the survival time was 23 months and 21 months respectively. Three patients were still in treatment follow-up in. Conclusions SC-NCC has high malignant degree, easy to metastasis, poor prognosis and high mortality rate. The diagnosis depends mainly on histopathology and immunohistochemistry. At present there is no norms and effective treatment options, are mostly used in surgery, chemotherapy and radiotherapy combined with comprehensive treatment.