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英国剑桥大学医学院Fearon等报道,把鼠补体C3与重组抗原模型鸡卵溶菌酶(HEL)融合可显著增强HEL的抗原性。他们给小鼠注射携带2个C3分子的HEL,产生的抗HEL抗体水平比单注射HEL的小鼠高1000倍;给小鼠注射携带3个C3分子的HEL,诱生的抗体水平增高1万倍。 Fearon等认为,C3所以能起如此显著的作用,是因为补体系统是天然免疫系统,在高等动物(如哺乳动物)中它的发生远早于获得性免疫系统。补体免疫由微生物的生化特征所触发,而抗体不能单独发现这些特征。然而,补体可把这个信息提供给获得性免疫系统。 C3与抗体产生之间似通过B淋巴细胞CD21受体介导,活化的B淋巴细胞为T细胞和抗体生成所必需。
Fearon et al reported that the fusion of murine complement C3 with the recombinant antigen model chicken egg lysozyme (HEL) could significantly enhance the antigenicity of HEL. They injected mice with two C3 molecules of HEL and produced anti-HEL antibodies 1000 times higher levels than mice injected with HEL alone. Injecting mice with three C3 molecules of HEL resulted in an increase in the level of antibodies induced by 10,000 Times Fearon believes that C3 can play such a significant role because the complement system is a natural immune system that occurs much earlier in the higher animals (such as mammals) than the adaptive immune system. Complement immunity is triggered by the biochemical characteristics of microorganisms, which antibodies can not detect alone. However, complement can provide this information to the adaptive immune system. C3 and antibody production seem to be mediated through the B lymphocyte CD21 receptor, activated B lymphocytes required for T cells and antibody production.