论文部分内容阅读
目的观察中药８１４对弹力酶诱导的金黄地鼠肺气肿的防治效果。方法随机设正常组、模型组、８１４防治组。模型组应用气管内注入弹力蛋白酶制造金黄地鼠肺气肿；防治组于注酶前两周以８１４灌胃。于实验开始后１月、２月、３月，分别测定三组动物的肺动脉压、血气、心脏指数、肺干湿质量比（ＤＷ／ＷＷ）；肺组织石蜡切片中ＭＬＩ、ＭＡＮ、ＰＡ／ＴＡ以显微微机图象处理系统测量。结果应用８１４后可使肺气肿组增加的肺干湿比恢复到与正常组无统计学差异；８１４防治组比单纯肺气肿组平均肺泡间隔（ＭＬＩ）减少，平均肺泡数（ＭＡＮ）、肺实质与总面积比（ＰＡ／ＴＡ）增加，皆有显著意义（Ｐ＜０．００１或Ｐ＜０．０５）。结论中药制剂８１４可减缓弹力酶引起的地鼠肺气肿病变的发生、发展。
Objective To observe the effect of traditional Chinese medicine 814 on the prevention and treatment of emphysema induced by elastase in golden hamster. Methods Randomly set normal group, model group, 814 control group. In the model group, intratracheal instillation of elastase was used to produce golden hamster emphysema; in the control group, gastric perfusion was performed at 814 two weeks before the injection of enzyme. Pulmonary arterial pressure, blood gas, cardiac index and pulmonary wet mass ratio (DW / WW) were measured in the three groups at January, February and March after the start of the experiment. MLI, MAN, PA / TA Measured with a microscope image processing system. Results After 814 treatment, the increased lung wet / dry ratio in emphysema group returned to normal group with no significant difference. The mean alveolar septum (MLI) in 814 group was lower than that in simple emphysema group. The mean alveolar number (MAN) Parenchyma and total area ratio (PA / TA) increased, both were significant (P <0.001 or P <0.05). Conclusion Chinese medicine preparation 814 can reduce the occurrence and development of hamster emphysema induced by elastase.