到2005年2月底,通过美国食品药物管理局(U.S.Food and Durug Administration,FDA)认证的治疗性抗体已达18种。从上世纪80年代至今,治疗性抗体的研究经历了高潮和低谷,现在又迎来了第二个春天。了解各类治疗性抗体的作用机制,把握住当前该类生药制品的发展趋势,才能把基础研究和制药产业紧密联系起来,开发出新药品。 By the end of February 2005, 18 therapeutic antibodies have been certified by the U.S. Food and Drug Administration (FDA). Since the 1980s, the study of therapeutic antibodies has experienced a climax and trough, and now usher in a second spring. Understand the mechanism of action of various therapeutic antibodies, to grasp the current trends in the development of such products in order to make the basic research and pharmaceutical industry closely linked to the development of new drugs.