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为研究血清胆汁酸测定的临床意义,作者对174例肝病患者作了早晨空腹血清总胆汁酸(F.TBA)浓度测定,并对90例慢性肝病患者进行熊脱氧胆酸(UDCA)经口负荷试验,结果如下。 F.TBA:正常人(40例)的值均小于10μmol/L。在各种肝病患者(174例)中,急性肝炎初期、肝硬变(失代偿型)、肝内性胆汁郁滞和肝外梗塞性黄疸病例的F.TBA的异常率达100%;在慢性肝病(慢性肝炎、脂肪肝、肝硬变)病例,其值分布于正常至高度异常之广范范围内。各种肝病间的F.TBA值颇多重叠,单次测定不能作出鉴别诊断。作者对急性肝炎恢复期患者(20例)进行一年的追踪观察发现,有12例初次F.TBA测定正常者,均不转变为慢性肝炎;而在8例初次F.TBA测定异常者中,有6例转变为慢性肝炎。从而认为,对F.TBA异
In order to study the clinical significance of serum bile acid determination, we measured the concentration of fasting serum total bile acid (FTAB) in 174 patients with liver disease and carried the oral load of ursodeoxycholic acid (UDCA) in 90 patients with chronic liver disease Test results are as follows. F.TBA: normal (40 cases) values ?? were less than 10μmol / L. In a variety of liver disease patients (174 cases), the abnormal rate of F.TBA in the early stages of acute hepatitis, liver cirrhosis (decompensated), intrahepatic cholestasis and extrahepatic infarction jaundice cases was 100%; in the Chronic liver disease (chronic hepatitis, fatty liver, cirrhosis) cases, the value distribution in the normal to a wide range of abnormalities. F.TBA values across a variety of liver diseases overlap, a single determination can not make a differential diagnosis. The author of the recovery of acute hepatitis patients (20 cases) one year follow-up observation found that 12 cases of normal first F.TBA determination did not change to chronic hepatitis; and in 8 cases of the first F. TBA abnormalities, Six cases converted to chronic hepatitis. So that, different from F. TBA