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1.25(OH)_2D_3是 VD_3的激素活性形式,起初认为1.25(OH)_2D_3与一种特异性,高亲和力的胞浆蛋白质结合而行使功能。现认为这种类固醇——受体复合物转移到细胞核,在胞核中影响 mRNA 的转录,以合成新的蛋白质。与1.25(OH)_2D_3特异结合的蛋白质目前已在几种涉及到 Ca~(++)转移的组织(小肠、骨、肾及乳腺)以及认为调节肾脏生成活性维生素 D 代谢的内分泌腺(甲状腺和甲状旁腺)中发现。新近研究发现。在脑和骨骼组织中存在该结合蛋白质,说明与1.25(OH)_2D_3结合的蛋白质在体内分布较广。虽然该激素在这些部位的功能尚不清楚,但很显然,1.25(OH)_2D_3比
1.25(OH)_2D_3 is the hormonal active form of VD_3, initially thought that 1.25(OH)_2D_3 binds to a specific, high-affinity cytosolic protein and functions. This steroid-receptor complex is thought to transfer to the nucleus and affect the transcription of mRNA in the nucleus to synthesize new proteins. Proteins that specifically bind to 1.25(OH)_2D_3 are present in several tissues (small intestine, bone, kidney, and breast) that involve Ca ++ transfer and endocrine glands that regulate the kidney to produce active vitamin D metabolism (thyroid and Parathyroid glands found in. Recent research found. The presence of this binding protein in brain and bone tissue indicates that the protein bound to 1.25(OH)_2D_3 is widely distributed in vivo. Although the function of this hormone in these sites is not clear, it is clear that 1.25(OH)_2D_3 ratio