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1目的 探讨转化生长因子 β 型受体 (TGF- β R)表达与大肠癌生物学行为的关系。 2方法 应用免疫组化技术检测 5 6例大肠癌术后标本及癌旁组织中 TGF- β R表达情况。 3结果 癌旁组织中 TGF- β R表达阳性率为 96 .6 4% ,原发癌组织表达阳性率为 44 .6 4% ,差异有显著性 (χ2 =30 .78,P<0 .0 1) ;无区域淋巴结转移者阳性率为 72 .0 0 % ,有区域淋巴结转移者阳性率为 2 2 .5 8% ,差异有显著性 (χ2 =13.6 8,P<0 .0 1)。 TGF- β R表达水平与肠壁浸润深度、Duke分期呈负相关。TGF- β R阳性者术后 3,5年生存率分别为 89.2 0 % ,78.15 % ,而阴性者分别为 76 .6 0 % ,43.75 % ,两者比较差异具有显著性 (χ2 =35 .46 ,P<0 .0 1)。 4结论 检测癌组织中 TGF- β R表达状况 ,有助于判断大肠癌生物学行为及预后。
1 Objective To investigate the relationship between the expression of transforming growth factor β receptor (TGF-βR) and the biological behavior of colorectal cancer. 2 Methods Immunohistochemistry was used to detect the expression of TGF-β R in 56 specimens of colorectal cancer and its adjacent tissues. 3 Results The positive rate of TGF-β R expression in adjacent non-cancerous tissues was 96.6%, the positive rate of primary cancerous tissues was 44.64%, the difference was significant (χ2 = 30.78, P <0. 0 1). The positive rate of non-regional lymph node metastasis was 72.0%. The positive rate of regional lymph node metastasis was 2.25%. There was significant difference (χ2 = 13.68, P <0.01). The expression of TGF-βR was negatively correlated with the depth of invasion and the Duke stage. The 3-year and 5-year survival rates of TGF-βR-positive patients were 89.2% and 78.15%, respectively, while the negative ones were 76.60% and 43.75% respectively, with significant difference between the two groups (χ2 = 35.46 , P <0. 01). CONCLUSION: Detecting the expression of TGF-βR in cancerous tissue is helpful to judge the biological behavior and prognosis of colorectal cancer.