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[目的]观察小牛脾提取物注射液(斯普林)联合化疗治疗晚期结直肠癌患者的近期疗效。[方法]将83例患者随机分为两组:单纯化疗组(对照组)40例,采用乐沙定加希罗达方案(Xelox方案)化疗,3周为一疗程;联合治疗组43例,化疗方案同对照组,并于每疗程第1d开始静脉滴注斯普林10ml/d,连用14d。评价患者的近期疗效、不良反应及生存质量。[结果]联合治疗组和对照组缓解率差异无统计学意义(P>0.05)。斯普林治疗7、14d后,联合治疗组患者外周血白细胞和血小板计数较对照组明显增多,差异有显著性(P<0.05)。血红蛋白和红细胞计数与对照组比较,没有明显变化。[结论]斯普林具有升高外周血象、提高患者对化疗耐受性的作用,值得临床推广应用。
[Objective] To observe the short-term curative effect of calf spleen extract injection (Spring) combined with chemotherapy on patients with advanced colorectal cancer. [Methods] Eighty-three patients were randomly divided into two groups: 40 patients in the chemotherapy alone group (control group), X-oxoxetine group (Xelox regimen) chemotherapy for 3 weeks; 43 patients in the combined treatment group Chemotherapy with the control group, and in the first day of each treatment began to intravenous injection of Spring 10ml / d, once every 14d. Evaluation of the patient’s immediate effect, adverse reactions and quality of life. [Results] There was no significant difference in remission rate between the combination therapy group and the control group (P> 0.05). Compared with the control group, the number of peripheral blood leukocytes and platelets in the combination therapy group increased significantly after 7 and 14 days of Spring treatment, with significant difference (P <0.05). Hemoglobin and red blood cell count compared with the control group, no significant change. [Conclusion] Spring has the effect of raising peripheral blood and improving patient tolerance to chemotherapy, which is worth popularizing.