青霉胺一直是治疗 Wilson 病的有效药物。近年来报道大剂量锌口服可通过减少肠道铜吸收而导致铜负平衡且毒性很低。经治疗后 K—F 环可消失而肝铜含量恢复正常。作者报道两例服锌后肝活检和放射性铜负荷试验显示体内铜贮下降。例1:男性20岁,诉震颤与言语不清。检查见面肌张力障碍,轻度构音障碍和上肢位置性震颤。裂 Penicillamine has long been a potent drug for treating Wilson’s disease. In recent years, it has been reported that large doses of zinc orally can cause negative copper balance and low toxicity by reducing intestinal copper absorption. After treatment K-F ring disappeared and liver copper content returned to normal. The authors report that two cases of zinc after liver biopsy and radioactive copper load tests showed a drop of copper storage in the body. Example 1: Male 20 years old, complained of tremor and verbal ill-defined. Check to see dystonia, mild dysarthria and upper extremity tremor. crack