临床上药物内耳中毒的发生主要取决于个体敏感性,它与不同人种、家族基因型、年龄、体质以及肾功能等因素相关。本实验通过观察幼年与成年豚鼠对庆大霉素内耳毒性的反应,探讨庆大霉素耳毒性与动物年龄的关系。 实验选用健康雄性豚鼠28只:幼年14只,4～6周龄,体重150～200克;成年14只,24～28周龄,体重500～750克。各年龄组随机分出7只给予硫酸庆 The incidence of clinical drug poisoning in the inner ear mainly depends on the individual sensitivity, which is related to different races, family genotype, age, constitution and renal function. In this study, the response of gentamicin to the inner ear of neonatal and adult guinea pigs was observed and the relationship between gentamicin ototoxicity and animal age was explored. 28 healthy male guinea pigs were selected in this experiment: 14 were young, 4 to 6 weeks old and weighing 150 to 200 grams; 14 were adults, 24 to 28 weeks old and weighing 500 to 750 grams. Each age group were randomly assigned to give seven days of sulfuric acid celebration