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目的观察埃索美拉唑治疗消化道溃疡的效果及对患者血清胃蛋白酶原PGⅠ及PGⅡ的影响。方法将80例消化道溃疡患者随机分为观察组和对照组各40例,观察组给予埃索美拉唑口服治疗,对照组给予奥美拉唑口服治疗,比较2组总有效率及治疗前后的血清胃蛋白酶原水平。结果观察组治疗总有效率为92.5%高于对照组的80.0%,差异有统计学意义(P<0.05)。治疗3d、7d、14d后血清胃蛋白酶原(PGⅠ及PGⅡ)水平均呈逐步递减趋势,且观察组各时间点血清胃蛋白酶原(PGⅠ及PGⅡ)水平明显低于对照组,差异均有统计学意义(P<0.05)。结论埃索美拉唑在消化道溃疡中的应用效果较好,有助于患者溃疡的尽早愈合,值得临床医学推广。
Objective To observe the effect of esomeprazole on peptic ulcer and its effect on serum pepsinogen PGⅠ and PGⅡ in patients. Methods Eighty patients with peptic ulcer were randomly divided into observation group (40 cases) and control group (40 cases). The observation group was orally treated with esomeprazole, while the control group was orally treated with omeprazole. The total effective rate was compared with that before treatment Serum pepsinogen levels. Results The total effective rate of observation group was 92.5% higher than 80.0% of control group, the difference was statistically significant (P <0.05). Serum PG (PGI and PGII) levels decreased gradually after 3d, 7d and 14d, and serum pepsinogen (PGⅠ and PGⅡ) levels in observation group were significantly lower than those in control group at each time point Significance (P <0.05). Conclusion The application of esomeprazole in the treatment of peptic ulcer is better, which will help to heal the ulcer in patients as soon as possible, which is worth popularizing in clinic.