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从土壤中筛选新抗生素产生菌工作已经进行了四十年。在第一个十年间发现了一系列迄今尚在临床使用的抗生素,成绩显著,被称为研究新抗生素的黄金时代。1960年代以后,由于经典的筛选模型和方法不断地被重复使用,使新化合物出现的机率大幅度下降。但抗生素使用后出现的耐药菌感染;勃致病菌(如脆弱拟杆菌)的出现;加之在抗仲瘤、抗病毒、抗真菌及原虫等方面迄今尚无令人满意的药物,都要求人们继续寻找新的、
It has been 40 years since screening of new antibiotic-producing bacteria from soil. In the first decade, a series of antimicrobials that have been clinically used to date were found with remarkable achievements. They are known as the golden age of studying new antibiotics. Since the 1960s, the chances of new compounds have dropped drastically as classical screening models and methods continue to be reused. However, the use of antibiotics after the emergence of drug-resistant bacterial infections; the emergence of Bo pathogens (such as Bacteroides fragilis) appear; coupled with anti-sore, antiviral, antifungal and protozoal aspects so far there is no satisfactory drug requirements People continue to look for new,