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采用小鼠抗大鼠Thy1.1单克隆抗体复制大鼠系膜增生性肾炎模型 ,分为益肾活血泄浊汤治疗组、模型组和正常组。每周测定大鼠 2 4h尿蛋白及尿潜血 ,于第 2、5、8周时测定血清白蛋白、肌酐及尿素氮 ,结束时测定血液流变学 ,并进行免疫荧光、光镜及电镜观察。结果表明 :与病理组结果相比 ,治疗组各项指标均有显著性差异 (P <0 .0 5～P <0 .0 1) ,形态学观察也显示治疗组较病理组损害减轻。提示益肾活血泄浊汤能够明显保护病鼠肾功能 ,有效防止血液粘度升高 ,并延缓肾硬化发展的进程
Mouse anti-rat Thy1.1 monoclonal antibody was used to replicate mesangial proliferative nephritis model and divided into Yishen Huoxue Xiezhuo decoction group, model group and normal group. The 24-hour urinary protein and occult occult blood were measured every week. Serum albumin, creatinine and urea nitrogen were measured at the 2nd, 5th, and 8th weeks. Hemorheology was measured at the end and immunofluorescence, light and electron microscopy were performed. . The results showed that: compared with the pathological group, the treatment group had significant differences in various indicators (P <0.05 ~ P <0.01), morphological observations also showed that the treatment group than the pathological group of reduced damage. Tips Yishen Huoxue Xiezhuo Decoction can obviously protect the kidney function of sick rats, effectively prevent the increase of blood viscosity, and delay the development of nephrosclerosis.