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本文报道了不同条件下血卟啉光敏剂PSD-001、癌光啉(PSD-007)与国内外现用血卟啉光敏剂HPD、光敏素Ⅱ及确认品HP、HVD、PP的薄层色谱分析。结果表明,PSD-001及癌光啉在薄层板上通常分离为2或3个主要区带,在高效板上分离为8～9个区带;与确认品对比,证明二者的PP含量均在3％以下,HVD的含量分别为2.5％和6.3％左右;癌光啉中的血卟啉含量远低于国内外所用的HPD,且不存在原点附近的组分,表明与光敏素Ⅱ不同;癌光啉中Rf0.65的组分含量显著地高于所有对照样品的相应组分。提示癌光啉是一种不同于光敏素Ⅱ和HPD的新光敏剂。
This article reports the thin-layer chromatograms of hematoporphyrin photosensitizers PSD-001, carcino-porphyrins (PSD-007) and hemochromatin photosensitizer HPD, photofrin II and confirmed products HP, HVD, and PP at home and abroad. analysis. The results showed that PSD-001 and carcinoline were usually separated into 2 or 3 main bands on thin plates and separated into 8 to 9 bands on high-efficiency plates; the content of PP was compared with that of the confirmed products. Below 3%, the content of HVD was 2.5% and 6.3% respectively; the content of hematoporphyrin in cancer photorin was much lower than HPD used at home and abroad, and there were no components near the origin, suggesting that with the photofrin II Different; the content of Rf 0.65 in the cancer photorinse was significantly higher than that of all the control samples. It is suggested that carboline is a new photosensitizer that is different from photofrin II and HPD.