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目的:观察原发性高血压(EH)患者血浆神经肽Y(NPY)浓度的变化。方法:选择EH患者211例,同期同年龄体检健康者237例为对照组。所有研究对象取清晨空腹静脉血,用放射免疫方法测定血浆NPY浓度。结果:1.EH患者血浆NPY浓度、体重指数(BMl)高于对照组(P<0.01);经协方差分析校正BMI后,EH患者血浆NPY浓度与对照组比较,差异仍有显著统计学意义(P<0.01)。2.不同血压级别之间血浆NPY浓度亦存在显著性差异(P<0.01),且NPY浓度随着血压级别的上升而升高。3.血浆NPY浓度与平均动脉压(MAP)、收缩压(SBP)、BMI呈正相关:多元逐步回归显示,MAP为NPY的独立预测因子。结论:EU患者的血浆NPY浓度升高,且增高趋势与高血压的严重程度有关。NPY可能与EH的病理生理进程有关,检测血浆NPY浓度可作为评价EU进程的指标。
Objective: To observe the changes of plasma neuropeptide Y (NPY) in patients with essential hypertension (EH). Methods: 211 patients with EH were selected, and 237 healthy subjects of the same age were selected as the control group. Fasting venous blood samples were taken from all the subjects and plasma NPY concentration was measured by radioimmunoassay. The plasma concentrations of NPY and body mass index (BMl) in patients with EH were significantly higher than those in the control group (P <0.01). After adjusting for BMI by covariance analysis, the plasma concentrations of NPY in EH patients were still significantly different from those in the control group (P <0.01). There was also significant difference in plasma NPY concentrations between different blood pressure levels (P <0.01), and NPY concentration increased with the blood pressure level. Plasma NPY concentration was positively correlated with mean arterial pressure (MAP), systolic blood pressure (SBP), and BMI. Multivariate stepwise regression showed that MAP was an independent predictor of NPY. Conclusions: Plasma NPY levels are elevated in patients with EU and the increasing trend is related to the severity of hypertension. NPY may be related to the pathophysiology of EH, plasma NPY concentration can be used as an indicator of the evaluation of the EU process.