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目的:探讨巨块型宫颈癌Ⅰb～Ⅱb期术前新辅助化疗的疗效及安全性。方法:对病理检查确诊为巨块型宫颈癌47例Ⅰb～Ⅱb期(Ⅰb期21例,Ⅱa16例,Ⅱb10例)患者采用PVB方案化疗2个疗程后,行子宫广泛性切除及盆腔淋巴清扫术,观察近期疗效。结果:38例化疗后肿瘤直径较化疗前有不同程度缩小,差异有统计学意义(P<0.05),化疗总有效率81.3%;13例肿块完全消退,7例术后病理标本中未见残留癌,手术切除率100%。结论:术前新辅助化疗可提高宫颈癌的近期疗效,为根治性手术创造条件,是治疗宫颈癌的一种新手段。
Objective: To investigate the efficacy and safety of preoperative neoadjuvant chemotherapy for giant-type cervical cancer Ⅰb ~ Ⅱb. Methods: Forty-seven patients with stage Ⅰb ~ Ⅱb (21 cases of stage Ⅰb, 16 cases of stage Ⅱa, and 10 cases of stage Ⅱb) diagnosed as giant-type cervical cancer by pathology were treated with PVB regimen for 2 cycles of chemotherapy, followed by extensive uterine resection and pelvic lymphadenectomy , Observe the short-term effect. Results: The diameter of tumor in 38 patients decreased to some extent after chemotherapy compared with that before chemotherapy (P <0.05). The total effective rate of chemotherapy was 81.3%. Thirteen tumors completely disappeared and no residual tumor was found in 7 cases Cancer, surgical resection rate of 100%. Conclusions: Preoperative neoadjuvant chemotherapy can improve the curative effect of cervical cancer and create conditions for radical surgery, which is a new way to treat cervical cancer.