趋化因子为分子量较小的可溶性蛋白,通过与其相应受体结合,诱使淋巴细胞、嗜酸粒细胞等炎性细胞趋化至炎症部位,释放细胞因子,从而导致粘液过度分泌,气道高反应性等哮喘病理生理改变。趋化因子及其受体的拮抗剂已成为研究治疗哮喘的新靶点。 Chemokines are soluble proteins with smaller molecular weight. They can induce inflammatory cells such as lymphocytes and eosinophils to chemoattract inflammation sites and release cytokines by binding with their corresponding receptors, resulting in excessive secretion of mucus and high airway Reactivity and other pathophysiological changes in asthma. Antagonists of chemokines and their receptors have become new targets for the study of asthma.