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慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)是以不完全可逆的气流受限进行性发展为特征的一类疾病。患病人数多,死亡率高,社会经济负担重,已成为一个重要的公共卫生问题,其发病机制及新的治疗靶点的探索迫在眉睫。COPD发病机理非常复杂,至今尚未完全清楚。
Chronic obstructive pulmonary disease (COPD) is a group of diseases characterized by limited and progressive development of airflow that is not fully reversible. It has become an important public health issue with a large number of patients and a high mortality rate and a heavy social and economic burden. Its pathogenesis and new therapeutic targets are extremely urgent. The pathogenesis of COPD is very complex and not yet fully understood.