目的:探讨三维适形放射治疗(3DCRT)非小细胞肺癌(NSCLC)的临床近期疗效和毒副反应。方法:对三维适形放疗的24例非小细胞肺癌患者(3DCRT组)临床资料进行分析,并与同期行常规放疗(RT)的18例非小细胞肺癌患者(对照组)的疗效和毒副反应进行对比。2组均每周照射5次,每次照射2 Gy。结果:3DCRT组有效率(CR+PR)为87.5%,常规放疗组为55.5%,两组差异无统计学意义(P>0.05)。两组急性放射性食管炎发生率分别为33.3%和50%;放射性肺炎发生率分别为29.1%和44.4%;白细胞下降发生率分别37.5%和61.1%,两组差异均无统计学意义(P>0.05)。结论:三维适形放射治疗NSCLC有较好的近期疗效,毒副反应较轻,远期疗效有待进一步观察。 Objective: To investigate the clinical efficacy and toxicity of three-dimensional conformal radiotherapy (3DCRT) for non-small cell lung cancer (NSCLC). Methods: The clinical data of 24 patients with non-small cell lung cancer (3DCRT) treated with three-dimensional conformal radiotherapy were analyzed and compared with 18 patients with non-small cell lung cancer (control group) treated with conventional radiotherapy (RT) The reaction is compared. 2 groups were irradiated 5 times a week, each irradiation 2 Gy. Results: The effective rate (CR + PR) of 3DCRT group was 87.5%, and that of conventional radiotherapy group was 55.5%. There was no significant difference between the two groups (P> 0.05). The incidence of acute radiation esophagitis was 33.3% and 50% respectively in the two groups. The incidences of radiation pneumonitis were 29.1% and 44.4% respectively. The incidences of leukopenia were 37.5% and 61.1% respectively. There was no significant difference between the two groups (P> 0.05). Conclusion: Three-dimensional conformal radiotherapy for NSCLC has a good short-term curative effect with mild toxicity and long-term efficacy needs further observation.