15名经活组织检查证明为前列腺癌的患者:用酮康唑治疗,每8小时400mg。有两名病人因故中止治疗,其它13名患者完成了至少6个月的治疗。酮康唑大大降低了镇痛药的需求;血清前列腺酸性磷酸酶浓度降至正常,睾丸酮浓度则减少。6个月后13名病人得到缓解。酮康唑的副作用是有限的。 Fifteen patients who had been diagnosed as having prostate cancer by biopsy were treated with ketoconazole at 400 mg every 8 hours. Two patients discontinued treatment for any reason and 13 other patients completed at least 6 months of treatment. Ketoconazole significantly reduced the need for analgesics; serum prostatic acid phosphatase levels dropped to normal and testosterone concentrations decreased. Thirteen patients were relieved 6 months later. The side effects of ketoconazole are limited.