p53基因是一种肿瘤抑制基因,正常功能是调控细胞增殖。肺癌、乳癌和直肠癌等肿瘤中均有p53蛋白的突变和缺失。研究表明,突变型p53蛋白不仅失去正常的肿瘤抑制基因作用,而且部分出现癌基因的促细胞增生作用。恶性胸水是肿瘤细胞胸腔浸润和转移的结果。本文对30例伴胸水的恶性肿? The p53 gene is a tumor suppressor gene and its normal function is to regulate cell proliferation. P53 protein mutations and deletions are present in lung cancer, breast cancer, and rectal cancer. Studies have shown that mutant p53 protein not only loses normal tumor suppressor genes, but also some of the oncogene promotes cell proliferation. Malignant pleural effusion is the result of infiltration and metastasis of tumor cells in the chest cavity. This article on 30 cases of malignant swelling with pleural effusion?