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目的观察锡类散抗炎镇痛效果。方法测定锡类散对大鼠血管通透性试验、小鼠耳肿胀试验、小鼠醋酸扭体试验、小鼠热板法致痛试验的影响。结果锡类散低、中、高剂量组及阳性对照组的大鼠血管通透性、小鼠耳肿胀度和醋酸所致小鼠扭体反应与阴性对照组比较,差异均有统计学意义(P<0.05)。热板法致痛试验中,锡类散中、高剂量组在给药后30min-120min有明显的镇痛作用,与阴性对照组比较差异均有统计学意义(P<0.05)。结论锡类散具有良好的止痛和抗炎药理作用,为扩大锡类散临床上用于痔瘘术后换药提供了科学依据。
Objective To observe the anti-inflammatory analgesic effect of tin powder. Methods The effect of tin powder on vascular permeability test in mice, ear swelling in mice, writhing acetic acid in mice and the hot plate test in mice were determined. Results Compared with the negative control group, there were significant differences in vascular permeability, ear edema in mice and writhing reaction induced by acetic acid in rats of low, medium, high dose group and positive control group P <0.05). In the hot plate test, the middle and high dose tin groups showed obvious analgesic effect at 30min-120min after administration, which had significant difference compared with the negative control group (P <0.05). Conclusion Tin powder has a good analgesic and anti-inflammatory pharmacological effects, for the expansion of tin scattered clinically used for dressing after hemorrhoids fistula provides a scientific basis.